An Enzyme‐Loaded Metal–Organic Framework‐Assisted Microfluidic Platform Enables Single‐Cell Metabolite Analysis

Single-cell analysis is an effective method to reveal cell heterogeneity. In their Research Article (e202302000), Yujun Song et al. report enzyme-loaded metal–organic framework-integrated microfluidic chip for highly efficient single-cell capture followed by real-time metabolite monitoring and analysis. By profiling intracellular glucose extracellular lactate, the platform could evaluate tumorigenicity of tumor cells in unprocessed whole blood samples.